STEAP1

Across TCGA patient cohorts, STEAP1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,904 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible STEAP1-associated genes across cancer lineages are STEAP2, STEAP2-AS1, and SLC2A11. Each is linked with STEAP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both STEAP1-to-partner and partner-to-STEAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, STEAP1 versus STEAP2 in OV, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP1→partner) and Y-score (partner→STEAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STEAP2 →	+1.500	+0.598	<.001	<.001	3	4
LUAD	STEAP2-AS1 →	+0.826	+0.886	<.001	<.001	3	4
HNSC	SLC2A11 →	-0.809	-0.736	<.001	<.001	3	3
GBM	FRS3 →	-0.592	-1.237	.005	.004	2	4
GBM	PSEN2 →	-0.434	-1.237	.004	.004	3	3
HNSC	PABPN1P1 →	-0.820	-0.622	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,904 associations by consensus.

STEAP1 vs STEAP2 — OV

Explore this scatter interactively →