STEAP1

Across TCGA patient cohorts, STEAP1 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STEAP1-associated genes across cancer lineages are RAB11AP2, RNU6-13P, and MIR6737. Each is linked with STEAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STEAP1-to-partner and partner-to-STEAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB11AP2 grouped by STEAP1-low versus STEAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP1→partner) and Y-score (partner→STEAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAB11AP2 →	+0.094	+4.242	<.001	.006	3	2
COAD	RNU6-13P →	+0.292	+4.308	.002	.009	3	2
BRCA	MIR6737 →	+0.618	+5.506	<.001	.005	3	1
BRCA	AKR1B1P5 →	+0.069	+5.441	<.001	.005	3	1
BRCA	LINC01584 →	+0.058	+5.378	<.001	.006	3	1
UCEC	RNU6-92P →	+0.253	+4.069	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

RAB11AP2 by STEAP1 expression — UCEC

Explore this box plot interactively →