STEAP1

Across TCGA cell cohorts, STEAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,255 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible STEAP1-associated GO terms across cancer lineages are Negative regulation of response to tumor cell, Negative regulation of immune response to tumor cell, and Extracellular matrix disassembly. Each is linked with STEAP1 in more than 6 cancer types. Because this analysis shows association rather than direction, both STEAP1-to-partner and partner-to-STEAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to tumor cell grouped by STEAP1-low versus STEAP1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP1→partner) and Y-score (partner→STEAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of response to tumor cell →	+0.178	+1.665	<.001	.001	3	7
OVARY	Negative regulation of immune response to tumor cell →	+0.178	+1.665	<.001	.001	3	7
SOFT_TISSUE	Extracellular matrix disassembly →	+0.156	+2.770	<.001	<.001	3	7
LARGE_INTESTINE	DTMP catabolic process →	+0.133	+1.904	.001	<.001	3	7
SOFT_TISSUE	Negative regulation of T cell activation →	+0.078	+1.993	<.001	.002	3	7
CNS	Adenylate cyclase-activating serotonin receptor signaling pathway →	-0.140	-2.065	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,255 associations by consensus.

Negative regulation of response to tumor cell by STEAP1 expression — OVARY

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