STEAP1

Across TCGA cell cohorts, STEAP1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible STEAP1-associated genes across cancer lineages are MYF6, OR1L6, and CENPVL1. Each is linked with STEAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STEAP1-to-partner and partner-to-STEAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by STEAP1-low versus STEAP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP1→partner) and Y-score (partner→STEAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYF6 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR1L6 →	+0.027	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CENPVL1 →	+0.182	+4.095	<.001	.009	3	1
LARGE_INTESTINE	F11 →	+0.062	+4.467	<.001	.004	3	1
SKIN	TECTB →	+0.312	+3.724	<.001	.004	3	1
SKIN	ARR3 →	+0.144	+3.402	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MYF6 by STEAP1 expression — LARGE_INTESTINE

Explore this box plot interactively →