STC2

Across TCGA patient cohorts, STC2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. COAD shows the largest number of these associations.

The most reproducible STC2-associated genes across cancer lineages are mTOR, RAD51, and Shc_pY317. Each is linked with STC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STC2-to-partner and partner-to-STC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by STC2-low versus STC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STC2→partner) and Y-score (partner→STC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.188	-2.115	.007	.019	3	2
UCEC	RAD51 →	+0.126	+3.000	.039	.036	3	2
SKCM	Shc_pY317 →	-0.326	-3.152	.001	.019	3	2
COAD	C-Raf_pS338 →	+0.195	+3.008	.018	.019	3	2
SKCM	RBM15 →	-0.599	-3.000	.004	.034	3	2
UCEC	JNK2 →	+0.204	+2.834	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

mTOR by STC2 expression — UCEC

Explore this box plot interactively →