STC1

Across TCGA patient cohorts, STC1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STC1-associated genes across cancer lineages are eEF2, Notch1, and Annexin-1. Each is linked with STC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STC1-to-partner and partner-to-STC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by STC1-low versus STC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STC1→partner) and Y-score (partner→STC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.280	+2.115	.021	.017	3	2
UCEC	Notch1 →	+0.123	+1.598	.010	.040	3	2
UCEC	Annexin-1 →	+0.500	+1.827	.005	.015	3	2
UCEC	Shc_pY317 →	-0.245	-3.169	<.001	<.001	3	2
SKCM	C-Raf →	+0.237	+3.000	.001	.035	3	2
UCEC	eIF4E →	+0.209	+3.713	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

eEF2 by STC1 expression — UCEC

Explore this box plot interactively →