STAU2

Across TCGA patient cohorts, STAU2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAU2-associated genes across cancer lineages are MEK1, MSH2, and mTOR_pS2448. Each is linked with STAU2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAU2-to-partner and partner-to-STAU2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by STAU2-low versus STAU2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAU2→partner) and Y-score (partner→STAU2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.574	+2.736	<.001	<.001	3	2
UCEC	MSH2 →	-0.316	-3.674	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.193	-2.893	<.001	.001	3	2
UCEC	Akt →	-0.177	-1.861	.035	.049	3	2
UCEC	EGFR_pY1068 →	-0.241	-3.321	.009	.009	3	1
UCEC	eIF4G →	+0.244	+3.169	.032	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MEK1 by STAU2 expression — UCEC

Explore this box plot interactively →