STAT6

Across TCGA patient cohorts, STAT6 mutation is significantly associated with the RNA expression of many other genes, with 1,531 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAT6-associated genes across cancer lineages are MIR7976, LINC01784, and RNA5SP191. Each is linked with STAT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT6-to-partner and partner-to-STAT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7976 grouped by STAT6-low versus STAT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT6→partner) and Y-score (partner→STAT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7976 →	+0.337	+2.061	<.001	.001	3	2
PRAD	LINC01784 →	+0.104	+7.939	<.001	.008	3	2
HNSC	RNA5SP191 →	+0.724	+6.936	<.001	<.001	3	2
UCEC	AP1S3 →	+0.500	+3.087	.001	<.001	3	2
UCEC	VBP1 →	+0.448	+1.673	.007	.003	3	2
UCEC	PRIMPOL →	+0.357	+2.343	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,531 associations by consensus.

MIR7976 by STAT6 expression — UCEC

Explore this box plot interactively →