STAT6

Across TCGA patient cohorts, STAT6 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAT6-associated genes across cancer lineages are Syk, TFRC, and ERK2. Each is linked with STAT6 in more than 2 cancer types. Because this analysis shows association rather than direction, both STAT6-to-partner and partner-to-STAT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Syk grouped by STAT6-low versus STAT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT6→partner) and Y-score (partner→STAT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Syk →	+0.289	+1.183	.026	.044	3	3
UCEC	TFRC →	+0.390	+3.169	.034	.018	3	2
UCEC	ERK2 →	+0.167	+1.736	.012	.007	3	1
UCEC	FOXO3a_pS318_S321 →	-0.115	-1.668	.007	.021	3	1
UCEC	GSK-3_pS9 →	-0.401	-2.115	.004	.016	3	1
UCEC	GSK-3a-b_pS21_S9 →	-0.316	-1.700	.033	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Syk by STAT6 expression — UCEC

Explore this box plot interactively →