STAT6

Across TCGA cell cohorts, STAT6 mutation is significantly associated with the RNA expression of many other genes, with 987 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAT6-associated genes across cancer lineages are SPATA31A7, LRRC52, and LMX1A. Each is linked with STAT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT6-to-partner and partner-to-STAT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31A7 grouped by STAT6-low versus STAT6-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT6→partner) and Y-score (partner→STAT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SPATA31A7 →	+0.043	+5.000	<.001	.005	3	2
BLOOD_Lymphoma	LRRC52 →	+0.535	+3.342	<.001	.008	3	2
KIDNEY	LMX1A →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	PRR32 →	+0.013	+5.000	<.001	.005	3	1
KIDNEY	OR13C5 →	+0.023	+5.000	<.001	.005	3	1
OESOPHAGUS	PRAMEF15 →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 987 associations by consensus.

SPATA31A7 by STAT6 expression — KIDNEY

Explore this box plot interactively →