STAT4

Across TCGA patient cohorts, STAT4 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAT4-associated genes across cancer lineages are Ku80, Notch1, and ASNS. Each is linked with STAT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT4-to-partner and partner-to-STAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by STAT4-low versus STAT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT4→partner) and Y-score (partner→STAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.199	+1.453	.015	.015	3	2
UCEC	Notch1 →	+0.196	+3.013	<.001	<.001	3	2
UCEC	ASNS →	+0.406	+2.000	.001	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.589	+2.019	.004	.005	3	2
UCEC	CD49b →	-0.244	-2.202	.013	.010	3	2
UCEC	C-Raf →	+0.124	+1.807	.012	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Ku80 by STAT4 expression — UCEC

Explore this box plot interactively →