STAT4

Across TCGA cell cohorts, STAT4 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STAT4-associated genes across cancer lineages are ITGAD, PRSS45P, and SLC36A3. Each is linked with STAT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT4-to-partner and partner-to-STAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by STAT4-low versus STAT4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT4→partner) and Y-score (partner→STAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ITGAD →	+0.058	+4.273	<.001	.006	3	2
SKIN	PRSS45P →	+0.017	+4.415	<.001	.007	3	2
SKIN	SLC36A3 →	+0.011	+4.467	<.001	.004	3	1
SKIN	OR6N1 →	+0.202	+4.415	<.001	.007	3	1
SKIN	OR13C5 →	+0.017	+5.022	<.001	.002	3	1
BREAST	APOBEC1 →	+0.025	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ITGAD by STAT4 expression — SKIN

Explore this box plot interactively →