STAT2

Across TCGA pan-cancer cohorts, STAT2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated STAT2 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher STAT2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated STAT2 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where STAT2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.886	1.000	.020	30	view →
CCRCC	OS	Median	IV	0.123	0.785	.009	26	view →
PDAC	DFS	Tertile	All	0.657	0.875	.007	13	view →
LUAD	DFS	Tertile	All	0.954	0.906	.021	3	view →
LSCC	OS	Median	All	0.698	0.847	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

STAT2–COAD (DFS)

Open the COAD breakdown →