STAT2

Across TCGA patient cohorts, STAT2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,997 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible STAT2-associated genes across cancer lineages are OAS3, OAS2, and STAT1. Each is linked with STAT2 in more than 9 cancer types. Because this analysis shows association rather than direction, both STAT2-to-partner and partner-to-STAT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, STAT2 versus OAS3 in LSCC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT2→partner) and Y-score (partner→STAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	OAS3 →	+1.224	+0.344	<.001	<.001	3	10
UCEC	OAS2 →	+1.629	+0.457	<.001	<.001	3	10
HNSC	STAT1 →	+1.439	+0.735	<.001	<.001	3	10
LSCC	ZBP1 →	+1.036	+0.265	<.001	<.001	3	10
GBM	XAF1 →	+1.295	+0.449	<.001	<.001	3	10
UCEC	EPSTI1 →	+1.370	+0.423	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,997 associations by consensus.

STAT2 vs OAS3 — LSCC

Explore this scatter interactively →