STAT2

Across TCGA patient cohorts, STAT2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAT2-associated genes across cancer lineages are Rad50, EGFR_pY1173, and eIF4E. Each is linked with STAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT2-to-partner and partner-to-STAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by STAT2-low versus STAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT2→partner) and Y-score (partner→STAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.202	-1.765	.026	.014	3	2
UCEC	EGFR_pY1173 →	+0.060	+1.441	.046	.029	3	1
UCEC	eIF4E →	+0.178	+2.169	.024	.003	3	1
UCEC	eIF4G →	+0.238	+1.415	.040	.046	3	1
UCEC	A-Raf_pS299 →	-0.097	-2.321	.030	.034	3	1
UCEC	GATA6 →	-0.116	-2.985	.045	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Rad50 by STAT2 expression — UCEC

Explore this box plot interactively →