STAT2

Across TCGA cell cohorts, STAT2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible STAT2-associated genes across cancer lineages are BEND2, SLC32A1, and PHOX2B. Each is linked with STAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT2-to-partner and partner-to-STAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BEND2 grouped by STAT2-low versus STAT2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT2→partner) and Y-score (partner→STAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BEND2 →	+0.012	+3.544	<.001	.009	3	1
BLOOD_Leukemia	SLC32A1 →	+0.904	+3.901	<.001	.006	3	1
BLOOD_Leukemia	PHOX2B →	+0.024	+4.365	<.001	.002	3	1
BLOOD_Leukemia	AWAT2 →	+0.012	+3.705	<.001	.007	3	1
BLOOD_Leukemia	TMEM132D →	+1.593	+3.881	<.001	.006	3	1
BLOOD_Leukemia	XAGE3 →	+0.094	+4.450	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

BEND2 by STAT2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →