STAT1

Across TCGA pan-cancer cohorts, STAT1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated STAT1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher STAT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated STAT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where STAT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.916	1.000	.010	108	view →
LUAD	DFS	Median	III,IV	0.755	0.296	<.001	23	view →
CCRCC	DFS	Tertile	IV	0.198	0.887	.024	16	view →
PDAC	OS	Median	II,III,IV	0.782	0.898	.008	7	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	3	view →
LSCC	DFS	Tertile	All	1.000	0.559	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

STAT1–COAD (DFS)

Open the COAD breakdown →