STAT1

Across TCGA patient cohorts, STAT1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAT1-associated genes across cancer lineages are TFRC, eEF2, and PCNA. Each is linked with STAT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both STAT1-to-partner and partner-to-STAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by STAT1-low versus STAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT1→partner) and Y-score (partner→STAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.474	+1.473	.003	.006	3	3
COAD	eEF2 →	+0.411	+3.584	<.001	.002	3	3
COAD	PCNA →	+0.388	+3.472	<.001	.002	2	3
BLCA	PRDX1 →	+0.255	+2.820	.025	.035	3	2
UCEC	EGFR_pY1068 →	-0.256	-1.947	<.001	<.001	3	2
COAD	eIF4E →	+0.245	+2.025	<.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

TFRC by STAT1 expression — UCEC

Explore this box plot interactively →