STAT1

Across TCGA cell cohorts, STAT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,364 significant associations in total. BONE shows the largest number of these associations.

The most reproducible STAT1-associated GO terms across cancer lineages are Response to interleukin-9, Negative regulation of epithelial cell differentiation involved in kidney development, and Interleukin-9-mediated signaling pathway. Each is linked with STAT1 in more than 18 cancer types. Because this analysis shows association rather than direction, both STAT1-to-partner and partner-to-STAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to interleukin-9 grouped by STAT1-low versus STAT1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT1→partner) and Y-score (partner→STAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Response to interleukin-9 →	+0.313	+1.445	<.001	<.001	3	19
BLOOD_Lymphoma	Negative regulation of epithelial cell differentiation involved in kidney development →	+0.338	+2.605	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Interleukin-9-mediated signaling pathway →	+0.284	+1.489	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Cellular response to interleukin-9 →	+0.284	+1.489	<.001	<.001	3	18
BLOOD_Lymphoma	Metanephric mesenchymal cell differentiation →	+0.477	+2.805	<.001	<.001	3	18
BLOOD_Lymphoma	Cellular response to type I interferon →	+0.141	+2.453	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,364 associations by consensus.

Response to interleukin-9 by STAT1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →