STARD9

Across TCGA patient cohorts, STARD9 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STARD9-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with STARD9 in more than 1 cancer types. Because this analysis shows association rather than direction, both STARD9-to-partner and partner-to-STARD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by STARD9-low versus STARD9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STARD9→partner) and Y-score (partner→STARD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.066	-1.388	.023	.041	3	1
UCEC	EGFR_pY1068 →	-0.264	-2.662	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.085	-1.115	.014	.026	3	1
UCEC	ERK2 →	+0.147	+1.765	.008	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.081	-1.312	.025	.027	3	1
UCEC	GAPDH →	+0.373	+1.999	.017	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

14-3-3_beta by STARD9 expression — UCEC

Explore this box plot interactively →