STARD7

Across TCGA patient cohorts, STARD7 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STARD7-associated genes across cancer lineages are STAT3_pY705, eIF4E, and HSP70. Each is linked with STARD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both STARD7-to-partner and partner-to-STARD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by STARD7-low versus STARD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STARD7→partner) and Y-score (partner→STARD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.448	-3.000	<.001	.001	3	2
UCEC	eIF4E →	+0.179	+2.321	.039	.034	2	2
UCEC	HSP70 →	-0.427	-2.449	.010	.019	3	1
UCEC	JNK2 →	+0.296	+3.594	<.001	.001	3	1
UCEC	MEK1 →	+0.422	+2.321	.005	.006	3	1
UCEC	Mre11 →	-0.082	-1.807	.020	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

STAT3_pY705 by STARD7 expression — UCEC

Explore this box plot interactively →