STARD5

Across TCGA pan-cancer cohorts, STARD5 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of STARD5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where STARD5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types STARD5 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, LSCC, and CCRCC are the cancer types where STARD5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STARD5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.672	<.001	10	view →
LSCC	Female	All	+0.819	<.001	8	view →
CCRCC	Male	All	+0.234	<.001	5	view →
PDAC	Male	All	+0.567	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

STARD5–COAD

Open the COAD breakdown →