STARD4

Across TCGA patient cohorts, STARD4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STARD4-associated genes across cancer lineages are eEF2, ATM, and A-Raf_pS299. Each is linked with STARD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STARD4-to-partner and partner-to-STARD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by STARD4-low versus STARD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STARD4→partner) and Y-score (partner→STARD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.364	+2.115	.019	.019	3	2
UCEC	ATM →	-0.553	-2.115	.005	.019	3	2
UCEC	A-Raf_pS299 →	-0.130	-2.321	.012	.034	3	1
UCEC	Gab2 →	+0.461	+2.807	.003	.003	3	1
UCEC	GATA6 →	-0.139	-1.992	.046	.031	3	1
UCEC	JNK_pT183_Y185 →	-0.200	-2.794	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eEF2 by STARD4 expression — UCEC

Explore this box plot interactively →