STARD3

Across TCGA pan-cancer cohorts, STARD3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STARD3 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher STARD3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STARD3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

LIHC, LUAD, and UCEC are the cancer types where STARD3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.031	0.777	<.001	12	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	9	view →
UCEC	DFS	Median	II,III,IV	0.922	0.438	.030	6	view →
BLCA	DFS	Median	All	1.000	0.327	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STARD3–LIHC (OS)

Open the LIHC breakdown →