STAP2

Across TCGA patient cohorts, STAP2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAP2-associated genes across cancer lineages are eIF4E, GSK-3a-b_pS21_S9, and INPP4B. Each is linked with STAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAP2-to-partner and partner-to-STAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by STAP2-low versus STAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAP2→partner) and Y-score (partner→STAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.179	+3.335	.039	.005	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.518	+2.009	.003	.017	3	1
UCEC	INPP4B →	-0.338	-2.459	.011	.019	3	1
UCEC	MEK1 →	+0.503	+4.087	<.001	<.001	3	1
UCEC	MSH2 →	-0.239	-1.807	.012	.027	3	1
UCEC	p62 Lck ligand →	+0.346	+2.321	.010	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by STAP2 expression — UCEC

Explore this box plot interactively →