STAP2

Across TCGA cell cohorts, STAP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,850 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible STAP2-associated GO terms across cancer lineages are Maintenance of blood-brain barrier, Regulation of heart rate by cardiac conduction, and Cell-cell adhesion mediated by cadherin. Each is linked with STAP2 in more than 10 cancer types. Because this analysis shows association rather than direction, both STAP2-to-partner and partner-to-STAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of blood-brain barrier grouped by STAP2-low versus STAP2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAP2→partner) and Y-score (partner→STAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Maintenance of blood-brain barrier →	+0.243	+2.541	<.001	<.001	3	11
OESOPHAGUS	Regulation of heart rate by cardiac conduction →	+0.278	+2.458	.002	.001	3	11
PANCREAS	Cell-cell adhesion mediated by cadherin →	+0.212	+2.234	<.001	<.001	3	10
OESOPHAGUS	Basolateral protein secretion →	+0.217	+2.308	.002	.007	3	10
STOMACH	Paracellular transport →	+1.252	+3.661	<.001	<.001	3	10
BLOOD_Leukemia	Positive regulation of blood-brain barrier permeability →	+0.832	+1.248	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,850 associations by consensus.

Maintenance of blood-brain barrier by STAP2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →