STAP1

Across TCGA patient cohorts, STAP1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAP1-associated genes across cancer lineages are ATM, FoxM1, and JNK2. Each is linked with STAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both STAP1-to-partner and partner-to-STAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by STAP1-low versus STAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAP1→partner) and Y-score (partner→STAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.579	-2.000	.001	.010	3	3
UCEC	FoxM1 →	+0.214	+1.584	.035	.036	3	1
UCEC	JNK2 →	+0.160	+2.000	.040	.010	3	1
UCEC	MEK1 →	+0.352	+2.000	.014	.010	3	1
UCEC	Notch1 →	+0.236	+3.169	<.001	<.001	3	1
UCEC	p27_pT198 →	+0.106	+2.459	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by STAP1 expression — UCEC

Explore this box plot interactively →