STAP1

Across TCGA cell cohorts, STAP1 mutation is significantly associated with the mutation status of many other genes, with 218 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAP1-associated genes across cancer lineages are ITGA3, MTMR9, and TFDP2. Each is linked with STAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAP1-to-partner and partner-to-STAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGA3 grouped by STAP1-low versus STAP1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAP1→partner) and Y-score (partner→STAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ITGA3 →	+5.339	+4.772	.004	.004	1	2
STOMACH	MTMR9 →	+4.807	+4.807	.008	.008	1	2
STOMACH	TFDP2 →	+4.807	+4.807	.008	.008	1	2
STOMACH	DNAI1 →	+4.807	+4.807	.008	.008	1	2
STOMACH	SERPINH1 →	+4.807	+4.807	.008	.008	1	2
STOMACH	CCDC27 →	+4.807	+4.807	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 218 associations by consensus.

ITGA3 by STAP1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →