STAMBPL1

Across TCGA patient cohorts, STAMBPL1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAMBPL1-associated genes across cancer lineages are Shc_pY317, cIAP, and 14-3-3_beta. Each is linked with STAMBPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAMBPL1-to-partner and partner-to-STAMBPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by STAMBPL1-low versus STAMBPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAMBPL1→partner) and Y-score (partner→STAMBPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.159	-2.999	.020	.035	3	2
UCEC	cIAP →	+0.124	+2.179	.044	.034	3	2
UCEC	14-3-3_beta →	-0.092	-2.973	.041	.035	3	1
UCEC	EGFR_pY1068 →	-0.248	-2.000	.028	.032	3	1
UCEC	FASN →	+0.353	+2.000	.047	.032	3	1
UCEC	FOXO3a_pS318_S321 →	-0.143	-3.575	.011	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Shc_pY317 by STAMBPL1 expression — UCEC

Explore this box plot interactively →