STAMBPL1

Across TCGA cell cohorts, STAMBPL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,934 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible STAMBPL1-associated GO terms across cancer lineages are Negative regulation of small GTPase mediated signal transduction, Positive regulation of cell-substrate junction organization, and Positive regulation of focal adhesion assembly. Each is linked with STAMBPL1 in more than 8 cancer types. Because this analysis shows association rather than direction, both STAMBPL1-to-partner and partner-to-STAMBPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of small GTPase mediated signal transduction grouped by STAMBPL1-low versus STAMBPL1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAMBPL1→partner) and Y-score (partner→STAMBPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of small GTPase mediated signal transduction →	+0.084	+0.913	<.001	.003	3	9
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.159	+1.985	.003	<.001	3	8
LUNG_NSCLC_LUSC	Positive regulation of focal adhesion assembly →	+0.144	+1.536	.001	<.001	2	9
LUNG_NSCLC_LUSC	Hepatocyte growth factor receptor signaling pathway →	+0.244	+1.910	<.001	<.001	3	8
BREAST	Barbed-end actin filament capping →	+0.194	+1.280	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Cellular hyperosmotic response →	+0.120	+1.556	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,934 associations by consensus.

Negative regulation of small GTPase mediated signal transduction by STAMBPL1 expression — SKIN

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