STAM2

Across TCGA patient cohorts, STAM2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAM2-associated genes across cancer lineages are Annexin-1, ARID1A, and eEF2. Each is linked with STAM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAM2-to-partner and partner-to-STAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by STAM2-low versus STAM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAM2→partner) and Y-score (partner→STAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.473	+2.019	.019	.017	3	2
UCEC	ARID1A →	-0.150	-1.992	.036	.009	3	2
UCEC	eEF2 →	+0.336	+2.087	.014	.005	3	1
UCEC	EGFR_pY1068 →	-0.228	-2.584	.018	.010	3	1
UCEC	eIF4E →	+0.171	+2.472	.034	.010	3	1
UCEC	FASN →	+0.336	+1.678	.026	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Annexin-1 by STAM2 expression — UCEC

Explore this box plot interactively →