STAG3L4

Across TCGA pan-cancer cohorts, STAG3L4 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated STAG3L4 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher STAG3L4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated STAG3L4 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

GBM and LSCC are the cancer types where STAG3L4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.764	0.361	.004	10	view →
LSCC	DFS	Median	All	0.388	1.000	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

STAG3L4–GBM (OS)

Open the GBM breakdown →