STAG3L2

Across TCGA pan-cancer cohorts, STAG3L2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated STAG3L2 data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher STAG3L2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STAG3L2 expression acts as an unfavorable survival marker, although some lineages such as UCS and BLCA show a favorable association.

UVM, UCS, and BLCA are the cancer types where STAG3L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.331	0.871	.001	60	view →
UCS	DFS	Median	IV	0.952	0.367	.001	54	view →
BLCA	OS	Median	III,IV	0.760	0.589	<.001	42	view →
LGG	DFS	Median	All	0.785	0.874	<.001	40	view →
LAML	DFS	Median	All	0.508	0.275	.001	40	view →
ACC	OS	Median	All	0.320	0.827	.001	32	view →
COAD	DFS	Median	All	0.718	0.835	.009	24	view →
UCEC	DFS	Tertile	All	0.797	0.898	.003	24	view →
READ	OS	Tertile	II,III,IV	0.903	0.290	.003	23	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.559	.010	22	view →
CESC	DFS	Quartile	III,IV	0.532	0.897	.005	22	view →
KIRC	DFS	Quartile	IV	0.201	0.574	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

STAG3L2–UVM (DFS)

Open the UVM breakdown →