STAG2

Across TCGA patient cohorts, STAG2 protein abundance is significantly associated with the RNA expression of many other genes, with 19,169 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible STAG2-associated genes across cancer lineages are E2F1, DKC1, and LAS1L. Each is linked with STAG2 in more than 7 cancer types. Because this analysis shows association rather than direction, both STAG2-to-partner and partner-to-STAG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, STAG2 versus E2F1 in UCEC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG2→partner) and Y-score (partner→STAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	E2F1 →	+1.241	+0.212	<.001	<.001	3	8
LSCC	DKC1 →	+0.787	+0.227	<.001	<.001	3	8
LSCC	LAS1L →	+0.472	+0.205	<.001	<.001	3	8
HNSC	CEP72 →	+0.874	+0.219	<.001	<.001	3	7
HNSC	BRIX1 →	+0.575	+0.220	<.001	<.001	3	7
UCEC	SGO1 →	+1.185	+0.275	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,169 associations by consensus.

STAG2 vs E2F1 — UCEC

Explore this scatter interactively →