STAG2

Across TCGA patient cohorts, STAG2 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAG2-associated genes across cancer lineages are ATM, Paxillin, and eIF4E. Each is linked with STAG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both STAG2-to-partner and partner-to-STAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by STAG2-low versus STAG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG2→partner) and Y-score (partner→STAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.459	-2.510	<.001	<.001	3	4
LUAD	Paxillin →	+0.432	+3.012	.005	.018	3	3
UCEC	eIF4E →	+0.214	+1.898	<.001	<.001	3	3
UCEC	GAPDH →	+0.345	+1.662	.011	.009	3	3
BRCA	53BP1 →	-0.479	-2.994	.008	.037	3	3
UCEC	CD31 →	-0.073	-1.041	.049	.011	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

ATM by STAG2 expression — UCEC

Explore this box plot interactively →