STAG2

Across TCGA cell cohorts, STAG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,625 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STAG2-associated GO terms across cancer lineages are Establishment of mitotic sister chromatid cohesion, Nuclear pore complex assembly, and Mitotic spindle assembly. Each is linked with STAG2 in more than 17 cancer types. Because this analysis shows association rather than direction, both STAG2-to-partner and partner-to-STAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of mitotic sister chromatid cohesion grouped by STAG2-low versus STAG2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG2→partner) and Y-score (partner→STAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Establishment of mitotic sister chromatid cohesion →	+0.133	+0.858	<.001	<.001	3	18
BREAST	Nuclear pore complex assembly →	+0.134	+0.818	<.001	<.001	3	14
LUNG_SCLC	Mitotic spindle assembly →	+0.094	+0.727	.002	<.001	3	13
LUNG_SCLC	Regulation of mitotic cytokinesis →	+0.152	+1.042	<.001	<.001	3	13
OVARY	Protein localization to condensed chromosome →	+0.147	+0.992	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Mitotic G2/M transition checkpoint →	+0.113	+1.108	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,625 associations by consensus.

Establishment of mitotic sister chromatid cohesion by STAG2 expression — LUNG_SCLC

Explore this box plot interactively →