STAG1

Across TCGA pan-cancer cohorts, STAG1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated STAG1 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher STAG1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated STAG1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

LSCC, OV, and CCRCC are the cancer types where STAG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.967	0.757	.003	25	view →
OV	DFS	Median	All	1.000	0.854	.037	12	view →
CCRCC	DFS	Tertile	II,III,IV	1.000	0.286	.011	10	view →
PDAC	DFS	Tertile	IV	0.934	0.228	.024	9	view →
LUAD	DFS	Median	All	0.745	0.428	.013	6	view →
HNSC	OS	Median	III,IV	0.945	1.000	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

STAG1–LSCC (OS)

Open the LSCC breakdown →