STAG1

Across TCGA patient cohorts, STAG1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,559 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible STAG1-associated genes across cancer lineages are ISY1, YPEL1, and ACVR2B. Each is linked with STAG1 in more than 5 cancer types. Because this analysis shows association rather than direction, both STAG1-to-partner and partner-to-STAG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, STAG1 versus ISY1 in LSCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG1→partner) and Y-score (partner→STAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ISY1 →	+0.553	+0.326	<.001	<.001	3	6
GBM	YPEL1 →	+0.728	+0.293	<.001	.002	3	6
LSCC	ACVR2B →	+0.802	+0.331	<.001	<.001	3	6
LSCC	CDS2 →	+0.429	+0.261	<.001	.002	3	5
UCEC	KLF12 →	+0.773	+0.150	<.001	.001	3	5
CCRCC	EPC2 →	+0.394	+0.199	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,559 associations by consensus.

STAG1 vs ISY1 — LSCC

Explore this scatter interactively →