STAG1

Across TCGA patient cohorts, STAG1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAG1-associated genes across cancer lineages are ATM, FoxM1, and INPP4B. Each is linked with STAG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both STAG1-to-partner and partner-to-STAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by STAG1-low versus STAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG1→partner) and Y-score (partner→STAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.414	-2.070	.001	.001	3	3
UCEC	FoxM1 →	+0.165	+1.321	.022	.005	3	2
UCEC	INPP4B →	-0.257	-2.070	.004	.001	3	2
UCEC	Notch1 →	+0.114	+1.232	.003	.021	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.282	-1.321	.024	.027	3	2
UCEC	PCNA →	+0.188	+2.247	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by STAG1 expression — UCEC

Explore this box plot interactively →