STAG1

Across TCGA cell cohorts, STAG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,841 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STAG1-associated GO terms across cancer lineages are Double-strand break repair via nonhomologous end joining, Negative regulation of cell cycle process, and Mitotic G2/M transition checkpoint. Each is linked with STAG1 in more than 17 cancer types. Because this analysis shows association rather than direction, both STAG1-to-partner and partner-to-STAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via nonhomologous end joining grouped by STAG1-low versus STAG1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG1→partner) and Y-score (partner→STAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.069	+0.860	<.001	.001	3	18
OVARY	Negative regulation of cell cycle process →	+0.061	+0.868	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Mitotic G2/M transition checkpoint →	+0.103	+1.030	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Spindle elongation →	+0.284	+1.109	<.001	.002	3	17
LUNG_SCLC	DNA synthesis involved in DNA replication →	+0.107	+0.680	<.001	.003	3	17
PANCREAS	Chromosome segregation →	+0.079	+0.545	.003	.007	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,841 associations by consensus.

Double-strand break repair via nonhomologous end joining by STAG1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →