STAG1

Across TCGA cell cohorts, STAG1 mutation is significantly associated with the RNA expression of many other genes, with 239 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAG1-associated genes across cancer lineages are PRKCG, OOSP2, and OR10J1. Each is linked with STAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAG1-to-partner and partner-to-STAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKCG grouped by STAG1-low versus STAG1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAG1→partner) and Y-score (partner→STAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRKCG →	+0.978	+3.362	<.001	.007	3	2
BREAST	OOSP2 →	+0.017	+4.781	<.001	.003	3	1
BREAST	OR10J1 →	+0.425	+4.781	<.001	.003	3	1
LARGE_INTESTINE	GCAT →	+1.287	+2.502	<.001	.005	3	1
LARGE_INTESTINE	MCM5 →	+0.661	+3.234	.005	.004	3	1
LARGE_INTESTINE	TNRC6B →	+0.604	+3.064	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 239 associations by consensus.

PRKCG by STAG1 expression — BLOOD_Lymphoma

Explore this box plot interactively →