Across TCGA pan-cancer cohorts, STAC3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated STAC3 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STAC3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STAC3 expression acts as an unfavorable survival marker.

HNSC, LIHC, and SKCM are the cancer types where STAC3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.081	0.768	<.001	48	view →
LIHC	DFS	Median	All	0.091	0.553	.013	9	view →
SKCM	OS	Median	All	0.465	0.785	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: STAC3 tumor-vs-normal RNA expression · all STAC3 data types