Across TCGA cell cohorts, STAC3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STAC3-associated genes across cancer lineages are TCF21, RAX, and KERA. Each is linked with STAC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAC3-to-partner and partner-to-STAC3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAC3→partner) and Y-score (partner→STAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCF21 →	+0.013	+4.705	<.001	.003	3	1
BLOOD_Leukemia	RAX →	+0.514	+4.705	<.001	.003	3	1
BLOOD_Leukemia	KERA →	+0.006	+4.551	.002	.004	3	1
BLOOD_Leukemia	PRR30 →	+0.026	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	KRTAP3-1 →	+0.028	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

STAC3 survival (RNA) · tumor vs normal (RNA) · all STAC3 data types