STAC2

Across TCGA patient cohorts, STAC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,151 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible STAC2-associated GO terms across cancer lineages are Focal adhesion assembly, Regulation of cell-substrate adhesion, and Cell-substrate junction organization. Each is linked with STAC2 in more than 18 cancer types. Because this analysis shows association rather than direction, both STAC2-to-partner and partner-to-STAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Focal adhesion assembly grouped by STAC2-low versus STAC2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAC2→partner) and Y-score (partner→STAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Focal adhesion assembly →	+0.076	+0.219	<.001	<.001	3	19
STAD	Regulation of cell-substrate adhesion →	+0.107	+0.287	<.001	<.001	3	18
SCLC	Cell-substrate junction organization →	+0.079	+0.814	<.001	<.001	3	18
STAD	Substrate adhesion-dependent cell spreading →	+0.107	+0.335	<.001	<.001	3	18
STAD	Neuron projection extension →	+0.064	+0.236	<.001	<.001	3	17
ESCA	Cytoplasmic sequestering of transcription factor →	+0.077	+0.411	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,151 associations by consensus.

Focal adhesion assembly by STAC2 expression — STAD

Explore this box plot interactively →