STAC2

Across TCGA cell cohorts, STAC2 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STAC2-associated genes across cancer lineages are ZNF366, ACER1, and SFTPB. Each is linked with STAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAC2-to-partner and partner-to-STAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF366 grouped by STAC2-low versus STAC2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAC2→partner) and Y-score (partner→STAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF366 →	+0.013	+4.906	<.001	.006	3	1
LARGE_INTESTINE	ACER1 →	+0.072	+4.145	.006	.001	3	1
LARGE_INTESTINE	SFTPB →	+0.189	+3.548	<.001	.004	2	2
LARGE_INTESTINE	IQCF5 →	+0.021	+3.700	<.001	.009	3	1
CNS	OR3A3 →	+0.309	+4.315	<.001	.006	3	1
BLOOD_Leukemia	GML →	+0.090	+3.567	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ZNF366 by STAC2 expression — OESOPHAGUS

Explore this box plot interactively →