STAB2

Across TCGA pan-cancer cohorts, STAB2 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated STAB2 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher STAB2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated STAB2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, THCA, and BRCA are the cancer types where STAB2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.928	0.604	.001	28	view →
THCA	DFS	Median	All	0.077	0.811	<.001	15	view →
BRCA	OS	Median	III,IV	0.500	0.906	.004	10	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
KIRP	DFS	Median	All	0.685	0.870	.027	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
LGG	OS	Median	All	0.173	0.830	<.001	6	view →
LUAD	OS	Median	III,IV	0.833	0.328	.016	5	view →
SKCM	OS	Median	All	0.927	0.854	.013	4	view →
PRAD	DFS	Median	All	0.789	0.935	.025	2	view →
LIHC	OS	Median	II,III,IV	1.000	0.695	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

STAB2–UCEC (DFS)

Open the UCEC breakdown →