ST8SIA4

Across TCGA pan-cancer cohorts, ST8SIA4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ST8SIA4 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ST8SIA4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ST8SIA4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where ST8SIA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.480	0.852	<.001	41	view →
CCRCC	OS	Tertile	All	0.981	0.573	.045	2	view →
LSCC	DFS	Quartile	II,III,IV	0.488	0.853	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ST8SIA4–LUAD (OS)

Open the LUAD breakdown →