ST8SIA4

Across TCGA patient cohorts, ST8SIA4 mutation is significantly associated with the RNA expression of many other genes, with 6,698 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST8SIA4-associated genes across cancer lineages are FDX1P2, OXSM, and BUB3. Each is linked with ST8SIA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ST8SIA4-to-partner and partner-to-ST8SIA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FDX1P2 grouped by ST8SIA4-low versus ST8SIA4-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA4→partner) and Y-score (partner→ST8SIA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	FDX1P2 →	+0.126	+4.341	<.001	.007	3	4
COAD	OXSM →	+0.355	+3.392	.006	.004	3	3
UCEC	BUB3 →	+0.564	+1.722	<.001	<.001	3	3
UCEC	CCDC174 →	+0.206	+1.562	.004	<.001	3	3
UCEC	SEC13 →	+0.394	+1.722	<.001	<.001	3	3
UCEC	RER1 →	+0.251	+2.839	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,698 associations by consensus.

FDX1P2 by ST8SIA4 expression — READ

Explore this box plot interactively →