ST8SIA4

Across TCGA patient cohorts, ST8SIA4 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST8SIA4-associated genes across cancer lineages are GAPDH, MIG-6, and MEK1. Each is linked with ST8SIA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ST8SIA4-to-partner and partner-to-ST8SIA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ST8SIA4-low versus ST8SIA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA4→partner) and Y-score (partner→ST8SIA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.358	+1.247	.025	.041	3	3
COAD	MIG-6 →	+0.103	+3.519	.020	.002	3	3
UCEC	MEK1 →	+0.476	+2.321	<.001	<.001	3	2
UCEC	Notch1 →	+0.113	+1.672	.007	.006	3	2
UCEC	Rad50 →	-0.179	-1.584	.013	.002	3	2
UCEC	Annexin-1 →	+0.532	+2.341	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

GAPDH by ST8SIA4 expression — UCEC

Explore this box plot interactively →