ST7L

Across TCGA patient cohorts, ST7L mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST7L-associated genes across cancer lineages are eIF4E, p62 Lck ligand, and 14-3-3_beta. Each is linked with ST7L in more than 1 cancer types. Because this analysis shows association rather than direction, both ST7L-to-partner and partner-to-ST7L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ST7L-low versus ST7L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST7L→partner) and Y-score (partner→ST7L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.170	+2.183	.040	.033	3	2
UCEC	p62 Lck ligand →	+0.307	+1.584	.016	.036	3	2
UCEC	14-3-3_beta →	-0.091	-2.295	.021	.033	3	1
UCEC	EGFR →	-0.199	-3.321	.001	.010	3	1
UCEC	Heregulin →	-0.118	-2.986	.014	.035	3	1
UCEC	JNK2 →	+0.205	+2.179	.008	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by ST7L expression — UCEC

Explore this box plot interactively →